Volume 83, March 2021, 111089

Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases


Spirulina-derived bioactive compounds possess antioxidant, antiinflammatory, immunostimulatory, and immunomodulatory properties

Natural antioxidants, antiviral compounds, and angiotensin-converting-enzyme inhibitors from Spirulina indicated their potential role as an immune potentiator and therapeutic agent

This review postulates the potential role of Spirulina-based nutraceuticals in combating coronavirus diseases


The outbreak of the coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 that has created huge trepidation worldwide, has a mortality rate of 0.5% to 1% and is growing incessantly. There are currently no therapies and/or vaccines that may help abate this viral disease, but the use of masks and social distancing can limit the spread. Boosting immunity has been a simple way to resist viral infection and limit fatalities. In this context, the use of nutraceuticals appears to be a potential panacea. The ability of algae-based nutraceuticals, mainly Spirulina, to boost immunity against viral diseases has already been reported clinically. Spirulina-based nutraceuticals boost the adaptive and innate immunity, and bioactive compounds, such as angiotensin-converting enzyme (ACE) inhibitor peptides, phycobiliproteins, sulfated polysaccharides, and calcium-Spirulan, can serve as antiviral agents. The presence of these molecules indicates its potential role in resisting infection and COVID-19 disease progression. This review focuses on the potential role of algal nutraceuticals as immune boosters to combat the human coronavirus and other viral diseases. The potential use of Spirulina-based nutraceuticals for combating COVID-19, its mechanism, and future directions have also been discussed.


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